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IN THIS ISSUE
Molecular Modelers Take On CAMD Challenge

The Growing Data Deluge: Three Things IT Should Do

Study Ties Genetic Variations to Schizophrenia
TransMed: Focus on IT to Improve Innovation
 
 

June 2008 Bio-IT World Issue Preview

Bio-IT World 2008 Conference & Expo: Complete coverage of this year's event, featuring keynote presentations from Josh Boger (Vertex), John Reynders (Johnson & Johnson), Linda Avey (23andMe), and much more.

Adaptive Clinical Trials: Industry insiders share their experiences to date with adaptive clinical trials, including the new and growing area of adaptively designed "seamless" Phase II/III combinations incorporating dose selection and sample size re-estimation.
 
Biopharma Economic Development: Global competition is heating up for the best research and manufacturing resources. Bio-IT World's annual report on biotech programs looks at Singapore, the UK, and the latest trends from across the U.S.

To advertise, contact Alan El Faye at 213-300-3886, Kay O. Christopher at 860-693-2991, or Tom Loughran at 781-972-5482.
Ad Closing: April 30

 
THIS WEEK IN BIO-IT
 

Molecular Modelers Take On Challenge with Eyes Wide Open
By Vicki Glaser

OpenEye Software wrapped up its ninth annual CUP (Customers, Users, Programmers) meeting last week by announcing the results of SAMPL-1 (Statistical Assessment of the Modeling of Proteins and Ligands), a prospective, blind challenge designed to evaluate protein and ligand modeling tools and methods and the predictive power of computer-assisted molecular design (CAMD).

There were no official winners or losers in SAMPL-1, and no rankings posted. In fact, participants could choose to remain anonymous or not reveal their results. "We need ongoing, independent, blind tournaments" such as SAMPL, which expose competitors to unseen data, said Paul Labute, President and CEO of Chemical Computing Group (CCG). Read more.

 

Dealing with the Data Deluge: Three Things IT Should Do
By Salvatore Salamone

It's no secret that life sciences organizations must deal with ever-growing volumes of data. New lab equipment, lab automation, and computer simulations are increasingly generating more and larger data files, all of which must be stored, backed up, and managed.

Unfortunately, the data management challenge will likely only get worse. The life sciences, like many other fields, are undergoing an unprecedented data explosion, according to new research released this month by IDC. Read more.

Read more stories from the latest issue of Inside IT.

 

Provisio Moves into the Business of Protocol Feasibility Assessment
By Deborah Borfitz

Patient recruitment and site selection expert Provisio Inc. has a new service to help trial-sponsoring companies better assess protocol feasibility -- line by line and patient by patient. The company's mammoth iTrials Data Universe contains information from more than 500,000 physicians with unique diagnoses/treatment histories on roughly 60 million patients. Read more.

Read more stories from the latest issue of eCliniqua. 

 

Last Week's Most-Read Bio-IT World Story
Commentary: Is Informed Consent as Ethical as It Could Be?

 

Bio-IT Briefs - April 1, 2008

Novartis and FDA complete two-year CRADA to define and test a process for qualifying preclinical safety biomarkers
Genetic clues to diabetes revealed in major collaboration
Sigma-Aldrich partners with Sunset Molecular Discovery to expand "Your Favorite Gene" search tool
RemedyMD and GulfStream Bioinformatics partner to offer translational research solutions for 75 new disease models
Integromics´ Real-Time StatMiner chosen by Genzyme for use in qPCR analysis. . . more

Bio-IT Briefs - March 26, 2008

Bio-Imaging acquires Phoenix Data Systems
Interactive Supercomputing launches parallel computing blog
U. of Basel scientist, Balzan Prize winner, deciphers genetic program of the eye
Collexis enhances services for BioMedExperts online scientific social network
Ingenuity Systems delivers key milestones in FDA collaboration to facilitate genomic data review...more

 
ELSEWHERE IN THE PRESS
 

Seeking Alternatives to Animal-Derived Drugs
Concern about the possibility of animal viruses has led to a renewed search for synthetic replacements for certain crucial medicines that are still derived from animal parts. New York Times.

Study Ties Genetic Variations to Schizophrenia
A new study has found that rare and previously undetectable genetic variations may significantly increase the risk that a person will develop schizophrenia. New York Times

FDA Deadlines May Impact Drug Safety
Harvard researchers have found that drugs approved right on deadline are more likely to cause safety problems later than those cleared with more time to spare. Washington Post.

Doubt Cast on Two Drugs Used to Lower Cholesterol
Two widely prescribed cholesterol-lowering drugs may not work and should be used only as a last resort, a panel of cardiologists said on Sunday. IHT/Reuters.

FDA's Woodcock Denies Agency Is Risk-Averse on Drugs
The newly appointed head of medicine approvals at the FDA has insisted that science rather than politics or pricing is behind the growing difficulties facing new pharmaceuticals attempting to reach the market. Financial Times (free content).

U.K. to Force Drugmakers to Share Clinical Trial Data
Britain plans to force pharmaceutical companies to share more information with regulators about clinical trials. Associated Press.

 
BIO-IT WORLD MARCH 2008
ISSUE HIGHLIGHTS
   

Compute Power Delivers Across Fields
By Allison Proffitt

VenturiOne, Applied Cytometry's newest flow cytometry software, features many advances for analyzing flow cytometry data. But it promises to do a great deal more than that.

The U.K.-based company specializes in software to streamline the analysis of flow cytometry data. VenturiOne employs a Microsoft Vista look and feel to make data analysis quick and intuitive. As flow cytometry technologies have advanced, VenturiOne has met those advances. From offering analysis of three color tags a decade ago, the company can now parse out 15 to 18 different colors. Read more.

 

TransMed: Focus on IT to Improve Innovation
By Vijay Pillai

To improve the probability of success in biomarker discovery, accurately classifying the patient population for a given disease or disease subtype is essential. Translational medicine - which attempts to more directly connect basic research to patient care - represents a fundamental shift in the pharmaceutical industry's approach to drug development. Historically, drug discovery and development had little connection to clinical medicine outside of leveraging the clinical setting for trials in the final stages of the drug development process. Together, translational medicine and adaptive trials will create more of a dynamic environment of constant study, experimentation, and adaptation. Read more.

 

 

LIFE SCIENCE JOBS

Mayo Clinic – Job #19191 - Unit Head – IT
Location:  Rochester, MN.  Oversee software development and support for research and operational activities for Health Sciences Research and Nursing Research departments. Recruit, manage, and mentor IT personnel; provide budget administration, client/vendor management, strategic planning and project coordination, planning, and estimating. Qualifications:  BS degree in computer science or similar field (master’s in computer science, management or health/clinical informatics desirable), and 6+ years’ professional IT.  Apply online at:
www.mayoclinic.org/jobs-rst.

Mayo Clinic – Job #19178- Unit Head – IT
Location:  Rochester, MN.  Responsible for project coordination, planning and estimating, as well as budget administration, client/vendor management and strategic planning; plus coordinating technical resources that support research projects, journal publications, grant/contract preparation and scholarly activities. Qualifications: BS degree in computer science or a related field plus 6+ years’ IT experience.  Apply online at:
www.mayoclinic.org/jobs-rst.

Titian Software - US Support Engineer
Become a key member of our Support staff by providing “best in class” services to our customers. Investigate, diagnose, resolve, and be responsible for resolution of customer support issues and liaise with our UK Software Development team to suggest, request and perform code and product changes based on field experience. For more information and to apply:
http://www.titian.co.uk/Careers/Vacancies.asp 

Lilly Singapore Center for Drug Discovery (LSCDD) - Associate Director of Informatics,
Lead and mentor a strong team for the Bioinformatics group at the Integrative Computational Sciences (ICS) department at LSCDD towards the development of novel algorithms, data analysis methods and software tools for drug discovery. Work closely with the Software Engineering group at ICS, and collaborate with the Discovery IT organization in Europe and USA. For additional information, or to apply visit:
LSCDD


Lilly Singapore Center for Drug Discovery (LSCDD)- Senior Bioinformatics Scientist,Contribute to the development of novel algorithms, data analysis methods and software tools for drug discovery as part of the Integrative Computational Sciences (ICS) department at LSCDD.  Work closely with informatics and software engineering peers at ICS, and collaborate with the Discovery IT organization in Europe and USA. The successful candidate will offer hands-on insight and expertise in tailored therapeutic informatics and statistical analyses at the post-genomic era. For additional information, or to apply visit: LSCDD   


Lilly Singapore Center for Drug Discovery(LSCDD) -Senior Software Engineer,
Join a strong team of software engineers in our Integrative Computational Sciences (ICS) at LSCDD. Collaborate with, and help develop integrated applications to process and visualize data from cutting-edge technologies used by scientists at Lilly Research Labs (LRL) and the Drug Discovery Research (DDR) teams. The Software Engineering team provides computational tools and tailored software solutions that enable the global effort of Tailored Therapeutics; ‘The Right Drug, at The Right Dose for The Right Patient at The Right Time'. For additional information, or to apply visit: LSCDD
 

Agilent Technologies-Asia Pacific - Job Requisition: 2021927
Job Title :   Application Engineer and Implementation Specialist for Lab Informatics Platform
Location(s) :  Bangalore, India.  Project management: small to large scale implementations, including integration/ validation of Agilent’s software platform.  Manage assigned customer account relationship, customer satisfaction and education of future Agilent plans.  On time and on budget implementation, focus Pharma, Petro and Chemical markets.  Qualifications:  BS/’MS Degree in Computer Engineering, or other related discipline or equivalent.
Apply

Agilent Technologies-Asia Pacific - Job Requisition:2021658, Job Title : Product Specialist – Laboratory Informatics Location(s) :  Bangalore, India.  Proactively understand customer needs and identify solutions to actively create business opportunities.  Manage a complex, enterprise solution sale with long sales cycle.  Develop approaches to achieve quota strategies.  Lead coordinated projects across organizations.  Solve complex broad range of problems.  Qualifications:  BS/MS Degree in Sciences, Engineering, Computer or equivalent plus 5 to 8 years work experience. Apply 

More Life Science Jobs ~ Add a Job Listing

 

FEATURED EVENTS

EMC World 2008, May 19-22, 2008, Las Vegas,NV

IIR - 12th Annual EDC & Beyond, April 14-16, 2008, Las Vegas, NV
 
InforSense Translational Research Symposium, May 2,2008, Boston, MA

The First International Workshop on Label-free biosensing  April  8-9, 2008,  Enschede, The Netherlands

BioInformatics Asia 2008, April 14-17, Singapore

The Post-Approval Summit  May 14-15, 2008, The Conference Center, Harvard Medical School, Boston, MA

The 1st Symposium on Protein Tomography -- May 1, 2008, Boston, MA

Med-e-Tel, The International Educational and Networking Forum for eHealth, Telemedicine and Health ICT, 16-18 April in Luxembourg.

TEPR 2008 -- May 17-21, 2008 Ft. Lauderdale,FL 

Best Practices Awards Program -- April 29, 2008, Boston, MA

MIT Professional Institute - 2008 Short Courses   Cambridge,MA

GOT Summit: Getting Optimized Tools for Diagnostics - May 19-21, 2008, Boston,MA

 

To have your event featured here, contact Lynn Cloonan for more information.
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FEATURED CONTENT

SGI's Meeting Today’s Computational Needs for Science

The quest to better understand disease mechanisms and find new treatments is driven by new laboratory technologies and ever-more sophisticated modeling and simulation efforts. As such, life sciences R&D investigations increasingly are relying on more powerful computing resources. The challenge is how to accommodate the broad mix of applications.
Addressing this issue, this paper produced by the Bio-IT World Custom Publishing Group discusses a new SGI Hybrid Computing Environment approach. It optimally uses shared memory systems, multi-processor clusters, and FPGAs to accelerate computational workflows. Download This Free Paper 


SGI's Supercharging Proteomics Discovery

The deeper study of proteins and their interactions can reveal scientific information once considered nearly untouchable to scientists and researchers. Today, unprecedented advancements in computing power are enabling the creation of mounds of proteomic based data along with the accompanying bottlenecks data can create.  Rather than just “simplify the experiment” to fit the computational resources an alternative is now available with the SGI Proteomics Appliance. This complimentary white paper, produced by the Bio-IT World Custom Publishing Group, looks at ways to use the Proteomic Appliance to handle the most intensive proteomics computing tasks facing science today. Download This Free Paper



Waters
NuGenesis SDMS: Improving Data Accessibility and Intellectual Property Managment

Global pharmaceutical company improves the accessibility and intellectual property management
of drug candidate data with Waters® NuGenesis® SDMS software.Download the case study.

 

To have your white paper featured here, contact Lynn Cloonan for more information.
EXCLUSIVE WEBCAST

NEW! Life Science Webcasts from Bio-IT World and Cambridge Healthtech Media Group

Bio-IT World proudly introduces Life Science Webcasts -- a series of informal conversations with leading researchers and executives in the bio-IT and biopharma arena. This week, Dr. Jerald Schindler (VP, late stage clinical development statistics, Merck) discusses e-clinical research with Bio-IT World's Kevin Davies.

View the Webcast Now

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Published by Cambridge Healthtech Media Group, division of CHI, Copyright © 2008; All rights reserved. Bio-IT World Weekly Update may not be reproduced, electronically or in print, by any means, mechanical or electronic, in whole or in part, without written permission of Cambridge Healthtech Media Group, 250 First Ave., Suite 300, Needham, MA, 02494. 
For reprints and/or copyright permission, please contact The YGS Group, 1808 Colonial Village Lane, Lancaster, PA 17601. Phone: 717-399-1900, ext. 110. Email: becky.mullaney@theYGSgroup.com