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| IN THIS ISSUE |
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James Watson's Personal Genome Published in Nature |
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EMD Serono Expands Cancer Research in Massachusetts |
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States Crack Down on Online Gene Tests |
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Life Scientists Get Their Game Faces On |
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| THIS WEEK IN BIO-IT |
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James Watson's Personal Genome Published in Nature
By Kevin Davies
Fifty-five years after James Watson co-authored the most famous paper in Nature magazine's history -- the discovery of the DNA double helix with Francis Crick -- his genome sequence is also gracing the pages of the famous scientific journal.
Following months of extensive review and revision, Nature finally publishes the paper reporting the Watson's personal genome, or "Project Jim" as it was known, this week. The sequencing itself was performed by 454 Life Sciences, part of Roche, led by its founder and past chairman, Jonathan Rothberg. The bioinformatics analysis was handled by scientists at the Baylor College of Medicine genome center, led by Director Richard Gibbs and bioinformatician David Wheeler. Read more.
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EMD Serono Expands Cancer Research in Massachusetts
By Kevin Davies
Merck Serono and its U.S. affiliate EMD Serono -- part of Germany's Merck KGaA -- are expanding EMD Serono's U.S. foothold with a $50 million expansion at its Billerica, Mass., research and manufacturing facility, creating 100 new jobs in the process.
"Since the U.S. market is very important, we'd like to enlarge our footprint in the USA," said Elmar Schnee, president of Merck Serono, told Bio-IT World. "Boston is a prime location, it's the hub of biotech not only for the U.S. but worldwide. It has great access to academia, hospitals, and other biotech companies, with which we can cooperate and advance our research." Read more.
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GNS: Building a "SNPs-to-Outcomes" Engine
By John Russell
Personal and consumer genomics are boiling right now. The excitement, fueled by the plummeting costs of DNA sequencing and the rise of companies like 23andMe, feels tangibly different than many earlier biotech trends.... Yet sifting through the coming data flood and connecting the dots in ways that accurately predict SNPS-to-outcomes remains a huge challenge. Gene Network Sciences CEO Colin Hill says flatly, "GNS is gunning to be the first group that really breaks this open, by having a scalable, supercomputer-driven automated platform that can turn that raw data into discoveries of the key SNPs driving the outcomes." Read more.
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Last Week's Most-Read Bio-IT World Story
Al Gore Helps Navigenics Launch Personal Genomics Service
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Bio-IT Briefs - April 18, 2008
- Beijing Genomics Institute installs Applied Biosystems' SOLiD System
- Open Biosystems launches Decode RNAi viral screening pools
- Ingenuity and Pfizer announce partnership promoting deployment of IPA...more
Bio-IT Briefs - April 15, 2008
- U.S. and Japanese scientists launch global alliance for pharmacogenomics
- Febit announces miRBase 11.0 Biochip
- Council, IDC release studies on migration from desktop computers to HPC
- Helicos enters molecular diagnostics collaboration with City of Hope
- Illumina announces iScan System and three products for cancer research...more
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| ELSEWHERE IN THE PRESS |
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States Crack Down on Online Gene Tests
The flashy new industry of personalized gene testing is experiencing some early blowback. Over the last six months, New York State's Department of Health has sent letters raising the specter of fines and jail time to six online gene-testing firms. Forbes.
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The $100 Genome
Forget the $1,000 genome. Some companies are looking far past that goal in the hope of creating a really inexpensive sequencing technology. MIT Technology Review.
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Pfizer CEO Stands by His Plan, Frustrating Investors
Pfizer CEO Jeffrey Kindler said he stands by his plan to reverse falling profit by boosting sales of newer drugs instead of making a large acquisition to add products. Bloomberg.
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Glaxo Signs microRNA Drug Development Deal with Regulus
Pharmaceutical giant GlaxoSmithKline inked a deal with Carlsbad-based Regulus Therapeutics LLC valued at up to $600 million to develop new microRNA drugs that target inflammatory disease, the companies said April 17. San Diego Business Journal.
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FDA Issues Pharmacogenomic Guidance
The FDA took the final step to harmonize pharmacogenomic definitions and sample coding guidance with that of Japan and the European Union by issuing its own guidance for comment. FDA News.
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BIO-IT WORLD APRIL 2008
ISSUE HIGHLIGHTS |
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Life Scientists Get Their Game Faces On
Borrowing technology from gamers, science speeds up.
By Mike May
A few years ago, Ryan Schneider, chief technology officer at Acceleware in Calgary, Alberta, and his colleagues were struggling to solve complex computing challenges such as biological-image reconstruction. Needing more speed than mere CPUs could provide, Schneider's team tried field programmable gate areas (FPGAs) and even Microsoft's Xbox, finally settling on graphics processing units (GPUs).
It turns out that GPUs accelerate more than games and graphics. GPUs - single-chip processors that provide extensive parallel programming - hit the PC market in 1999, handling graphics tasks, including rendering and transformation. "As compared to conventional CPUs, GPUs consist of high-bandwidth memories and more floating point-hardware units," says Dinesh Manocha, a professor in the department of computer science at the University of North Carolina at Chapel Hill. Read more.
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Breaking the Rule (of Five)
Ensemble Discovery believes a new class of therapeutic compounds - and the novel means to synthesize them - could transform the drug discovery process.
By Kevin Davies
For decades, most drug discovery programs have essentially focused on two very different classes of molecules. On the one hand, small molecular weight compounds plucked from massive libraries, the traditional domain of big pharma. At the opposite end of the scale, much larger biologics, such as recombinant antibodies, have found increasing success in recent years
But a small biopharma in Cambridge, Mass., Ensemble Discovery, believes that a new class of compounds - not very imaginatively called the Ensemblins - could provide new leads against a variety of intractable targets, even protein-protein interactions. Read more.
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LIFE SCIENCE JOBS
Paradigm-Sales/Business Development IT Solutions and Services
Paradigm (www.Paradigminfotech.com) is a global IT services and solutions provider. Paradigm has over 1000 employees and is the recipient INC. 500 and D&T Fast 50 consistently. Paradigm is looking for SALES / BUSINESS DEVELOPMENT PEOPLE. Experience: 2-3 years Direct sales experience in Software Solutions or Services including Application development or support and preferably selling to Pharmaceutical, CROs or Health care industries. Location:Columbia, MD,Contact: Erin Lowman, erin@paradigminfotech.com, 410-872-1008 x 100
Lexicon Pharmaceuticals, Inc. - Systems Administrator (23835)
A biopharmaceutical company focused on discovering breakthrough treatments for human disease seeks a highly qualified Systems Administrator with Unix background to maintain the Unix computing environment high-performance computing systems and laboratory devices in our Princeton, New Jersey location. Candidates experienced in Cheminformatics and/or high performance computing (HPC) are highly preferred. Oracle Database Administration expertise is a plus. for complete details on this position visit: http://www.lexpharma.com/careers/opportunities.php For immediate consideration, please send your CV to opportunities@lexpharma.com.
Mayo Clinic Job #19191 - Unit Head IT
Location: Rochester, MN. Oversee software development and support for research and operational activities for Health Sciences Research and Nursing Research departments. Recruit, manage, and mentor IT personnel; provide budget administration, client/vendor management, strategic planning and project coordination, planning, and estimating. Qualifications: BS degree in computer science or similar field (masters in computer science, management or health/clinical informatics desirable), and 6+ years professional IT. Apply online at: www.mayoclinic.org/jobs-rst.
Mayo Clinic Job #19178- Unit Head IT
Location: Rochester, MN. Responsible for project coordination, planning and estimating, as well as budget administration, client/vendor management and strategic planning; plus coordinating technical resources that support research projects, journal publications, grant/contract preparation and scholarly activities. Qualifications: BS degree in computer science or a related field plus 6+ years IT experience. Apply online at: www.mayoclinic.org/jobs-rst.
Titian Software - US Support Engineer
Become a key member of our Support staff by providing best in class services to our customers. Investigate, diagnose, resolve, and be responsible for resolution of customer support issues and liaise with our UK Software Development team to suggest, request and perform code and product changes based on field experience. For more information and to apply: http://www.titian.co.uk/Careers/Vacancies.asp
Lilly Singapore Center for Drug Discovery (LSCDD) - Associate Director of Informatics,
Lead and mentor a strong team for the Bioinformatics group at the Integrative Computational Sciences (ICS) department at LSCDD towards the development of novel algorithms, data analysis methods and software tools for drug discovery. Work closely with the Software Engineering group at ICS, and collaborate with the Discovery IT organization in Europe and USA. For additional information, or to apply visit: LSCDD
Lilly Singapore Center for Drug Discovery (LSCDD)- Senior Bioinformatics Scientist,Contribute to the development of novel algorithms, data analysis methods and software tools for drug discovery as part of the Integrative Computational Sciences (ICS) department at LSCDD. Work closely with informatics and software engineering peers at ICS, and collaborate with the Discovery IT organization in Europe and USA. The successful candidate will offer hands-on insight and expertise in tailored therapeutic informatics and statistical analyses at the post-genomic era. For additional information, or to apply visit: LSCDD
Lilly Singapore Center for Drug Discovery(LSCDD) -Senior Software Engineer,
Join a strong team of software engineers in our Integrative Computational Sciences (ICS) at LSCDD. Collaborate with, and help develop integrated applications to process and visualize data from cutting-edge technologies used by scientists at Lilly Research Labs (LRL) and the Drug Discovery Research (DDR) teams. The Software Engineering team provides computational tools and tailored software solutions that enable the global effort of Tailored Therapeutics; The Right Drug, at The Right Dose for The Right Patient at The Right Time'. For additional information, or to apply visit: LSCDD
Agilent Technologies-Asia Pacific - Job Requisition: 2021927
Job Title : Application Engineer and Implementation Specialist for Lab Informatics Platform
Location(s) : Bangalore, India. Project management: small to large scale implementations, including integration/ validation of Agilents software platform. Manage assigned customer account relationship, customer satisfaction and education of future Agilent plans. On time and on budget implementation, focus Pharma, Petro and Chemical markets. Qualifications: BS/MS Degree in Computer Engineering, or other related discipline or equivalent. Apply
Agilent Technologies-Asia Pacific - Job Requisition:2021658, Job Title : Product Specialist Laboratory Informatics Location(s) : Bangalore, India. Proactively understand customer needs and identify solutions to actively create business opportunities. Manage a complex, enterprise solution sale with long sales cycle. Develop approaches to achieve quota strategies. Lead coordinated projects across organizations. Solve complex broad range of problems. Qualifications: BS/MS Degree in Sciences, Engineering, Computer or equivalent plus 5 to 8 years work experience. Apply
More Life Science Jobs ~ Add a Job Listing
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FEATURED EVENTS
The 1st Symposium on Protein Tomography -- May 1, 2008, Boston, MA
InforSense Translational Research Symposium, May 2,2008, Boston, MA
Put MIT to work for you - ASP Info Session May 6, Cambridge,MA
The Post-Approval Summit May 14-15, 2008, The Conference Center, Harvard Medical School, Boston, MA
TEPR 2008 -- May 17-21, 2008 Ft. Lauderdale,FL
EMC World 2008, May 19-22, 2008, Las Vegas,NV
BIO International Convention - June 17 20, 2008, San Diego Convention Center, San Diego, CA
GOT Summit: Getting Optimized Tools for Diagnostics - May 19-21, 2008, Boston,MA
Best Practices Awards Program -- April 29, 2008, Boston, MA
To have your event featured here, contact Lynn Cloonan for more information.
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| FEATURED CONTENT |
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SGI's Meeting Todays Computational Needs for Science
The quest to better understand disease mechanisms and find new treatments is driven by new laboratory technologies and ever-more sophisticated modeling and simulation efforts. As such, life sciences R&D investigations increasingly are relying on more powerful computing resources. The challenge is how to accommodate the broad mix of applications.
Addressing this issue, this paper produced by the Bio-IT World Custom Publishing Group discusses a new SGI Hybrid Computing Environment approach. It optimally uses shared memory systems, multi-processor clusters, and FPGAs to accelerate computational workflows. Download This Free Paper
SGI's Supercharging Proteomics Discovery
The deeper study of proteins and their interactions can reveal scientific information once considered nearly untouchable to scientists and researchers. Today, unprecedented advancements in computing power are enabling the creation of mounds of proteomic based data along with the accompanying bottlenecks data can create. Rather than just simplify the experiment to fit the computational resources an alternative is now available with the SGI Proteomics Appliance. This complimentary white paper, produced by the Bio-IT World Custom Publishing Group, looks at ways to use the Proteomic Appliance to handle the most intensive proteomics computing tasks facing science today. Download This Free Paper
To have your white paper featured here, contact Lynn Cloonan for more information.
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| EXCLUSIVE WEBCAST |
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NEW! Life Science Webcasts from Bio-IT World and Cambridge Healthtech Media Group
Bio-IT World proudly introduces Life Science Webcasts -- a series of informal conversations with leading researchers and executives in the bio-IT and biopharma arena.
This week, Dr. David Wheeler, co-director of Bioinformatics of the Human Genome Sequencing Center, Baylor College of Medicine, discusses "Project Jim: James Watson's Personal Genome" with Bio-IT World's Kevin Davies.
View the Webcast Now
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